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In this study, we used 3PN zygotes to investigate the specificity and fidelity of the CRISPR/Cas9 system.
In this study, Prof. Huang used tripronuclear (3PN) zygotes ("non-viable" embryos) to investigate the specificity and fidelity of the CRISPR/Cas9 system.
Since G-protein-coupled receptors that are designed to detect different kinds of external signals can generate the same kind of intracellular response, effective signaling requires that there are mechanisms to increase signal specificity and fidelity.
Indicator species analysis finds both dominant and non-dominant species that have high specificity and fidelity to a given class using a permutation test to assign an indicator value and associated p-value to those species (Dufrene and Legendre 1997) and any set of alternative classifications can be compared based on those metrics (Dufrene and Legendre 1997).
Using the Indicator Value Index, which ranks species according to their specificity and fidelity across sites, along with farmer consultation we found seven indicator taxa of soil quality that could greatly facilitate future evaluation of land management impacts by farmers and technicians in the region.
Vesicular transport specificity and fidelity are directed by vesicular membrane proteins and small molecular weight Rab GTPases [16].
As the noise increases, sensitivity, specificity, and fidelity decrease.
Sensitivity, specificity and fidelity are defined in the text.
Quantitative RT PCR methodology was designed to optimise the specificity and fidelity of the assay.
The authors do a nice job verifying the specificity and fidelity of their system.
Specificity and fidelity of signal transduction are crucial for cells to respond efficiently to changes in their environment.
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