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When describing the L3-specific chitinase of A. viteae, Wu et al., identified a protein of similar molecular weight as the L3-specific chitinase present in mf that displayed the opposite temperature specificity (expression at 27°C, not 37°C) [ 69], suggesting the presence of an additional chitinase functional within the insect vector.
We demonstrate that specificity, expression kinetics, and protein design are crucial parameters for efficient gene repair and that our two-step assay allows one to go quickly from design to testing to successful employment of the custom nucleases in human cells.
This is because other properties such as specificity, expression level and stability are also important.
Substrate specificity, expression and localization of many members of PIPs, TIPs and NIPs have been investigated.
Moreover HNF1A and HNF4A were identified as specifier (high specificity expression) hubs by the experimental work of FANTOM Consortium [ 9].
The above-described connections between tissue specificity, expression level, and expression variance and sex-bias may offer explanations for this rapid rate of evolution.
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In particular, while the generic nature of sympathy (as expressed by #prayforboston) might not have any geographic specificity, expressions of solidarity (using #bostonstrong) would be expected from cities with deeper ties to Boston that include shared regional or cultural identities.
Our partial correlation analysis indicated that the impact of extracellularity on mammalian protein evolutionary rate is also independent from those of tissue-specificity, expression level, gene compactness, and the number of protein protein interactions and, surprisingly, is the strongest among all the factors we examined.
Its substrate-specificity and tissue-specific expression make it a promising target for treatment of diabetes, metabolic syndrome and cancer, but few GLUT5 inhibitors are known.
We divided the organ/tissue-specific genes into 7 clusters based on the organ/tissue specificity of expression.
These genes had medium levels of tissue specificity of expression, and there was a tendency for MHC genes to have higher levels of expression specificity (Table 1).
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