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If a 'study' is defined as a phase III design leading to a sensitivity and specificity estimate of one or more RDTs in a specific patient population, then three of the 21 included records contained results of more than one unique study.
The summary estimate for sensitivity, however, was lower 79.2%, and more variable than the specificity estimate.
The summary specificity estimate was 70% or more for a threshold of 0.22 or above.
We aimed for a sensitivity and specificity estimate pooled at regional level.
The specificity estimate was lower than that in 2 other evaluations (9, 10 ) (38% vs. 50%and55%5%, respectively).
We therefore used 90% as the specificity estimate for MRI-targeted biopsy in the decision analysis, the same as that of TRUS-guided biopsy.
Similar(44)
Sensitivity and specificity estimates were computed for the validity analysis.
This method is based on a two-phase study design using an external data set for sensitivity and specificity estimates.
The antibody-positive ratio was 51.9%, analyzed using the three antigenic peptides; the sensitivity and specificity estimates at the cutoff point 77 mP were 85.4% and 98.6%, respectively.
The pooled specificity estimates for (18 F-FDG PET/CT (93%) and SPECT (818 F-FDG significantly higher than MRI (76%) (PET/CT033 and 0.042, respectively).
However, surgically unverified cases are often not considered in these studies, leading to verification bias, which can falsely increase the sensitivity and decrease the specificity estimates.
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