Sentence examples for specificity engineering from inspiring English sources
Furthermore, we consider more recent aspects of T cell specificity engineering.
As specificity engineering cases accumulate, understanding the mechanisms of the specificity determination will increase.
In addition, it would lay the ground for substrate specificity engineering of fungal A domains.
Coenzyme specificity engineering in xylose reductase (XR; NADPH → NADH) and xylitol dehydrogenase (XDH; NAD+ → NADP+) was useful to render the two-step isomerization of xylose a more nearly redox-neutral process [ 15- 17, 20].
Combined with the above-mentioned amenability to substrate specificity engineering, the NRPS-like protein could serve as a promising biocatalyst for in situ aldehyde generation for multistep one-pot synthesis.
Future structural studies of DUB polyUb complexes may allow DUB specificity engineering to generate enzymes with improved specificity, which would be beneficial for Ub chain restriction analysis and deeper understanding Ub chain biology.
As glycosyltransferases found in nature often show distinct substrate specificity, glycosyltransferase engineering is an important research field.
Applications of the esterase reaction in the design of novel antitumor compounds and improvements in the esterase activity and/or specificity by engineering CA active site will be described.
However, since the DNA-binding domain of these nucleases determines their site specificity, re-engineering the binding domain sequence is essential for each new target site.
Our studies therefore offer direct evidence and a new perspective on how to generate a post-selection CD4+ T cell repertoire with desired antigen specificities, through engineering the positively selecting self-peptide.
By contrast, biochemical approaches have attracted great attention because ample biosynthetic information and sophisticated toolboxes have been made available to change reaction specificity through protein engineering, domain swapping, pathway engineering, addition of substrate analogs, and mutagenesis.
