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Next-generation drugs would be designed for diseases subtypes with more specificity, efficacy and lower toxicity.
However, next-generation drugs would be designed for disease subtypes with more specificity, efficacy and lower toxicity.
In this review, we discuss keys to success in this development process including choosing predictors of specificity, efficacy, duration of action, and safety of the medications in disease models of acute and chronic drug abuse.
It is necessary to develop miR inhibitors or mimics which possess higher specificity, efficacy, and safety.
Selection of antiseptics is based on their specificity, efficacy, substantivity, safety, stability and plaque control.
Comparison of existing, development of new miRNA inhibitors and miR-mimics and optimization with respect to specificity, efficacy and toxicity.
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This suggests that use of isoform-specific HDAC inhibitors may increase the specificity and efficacy of these drugs in the treatment of psychiatric disorders.
Apart from providing insights into the disease process reporter mice harboring transgenes can also provide highly specific mechanistic information on the biological specificity and efficacy of therapeutic agents.
215 Moreover, the membrane of EMVs harbors donor cell-specific factors (eg, GPI-anchored proteins) that enable the EMVs to target specific acceptor cells for transfer of their mi/mRNA contents with exquisite specificity and efficacy.
The high specificity and efficacy of these nanoparticles were further reinforced by in vivo experiments [52].
The rapid rise of antibody-based therapies is largely due to their desirable safety profile, target specificity, and efficacy.
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