Sentence examples for specificity drift from inspiring English sources

As with the PKCγ mutants, the PSPL experiments validated the specificity drift in PKD1 D665N.

We identified and experimentally confirmed three striking examples of cancer mutations directly leading to a catalytic specificity drift, PKD1 D665N, PKCγ D484N, and M501I.

As shown in Figures 4E and S4, two out of the three downstream rewiring mutations cause a specificity drift of a magnitude comparable to the specificity difference that exists between different wild-type human kinases.

As shown in Figures 4B and S4, experimental determination of the peptide specificity of both variants by positional scanning peptide library (PSPL) (Hutti et al., 2004) corroborated the specificity drift of both these mutants.

With these validated examples at hand, we set out to further investigate whether other cancer mutations could cause similar dramatic specificity drifts and switches in other human kinases.

These, more subtle DNA binding preferences could potentially change faster than and independently of the canonical core DNA recognition motif, and could thus also allow TF specificity to slowly drift in evolution.

Our results suggest that morphological divergence is not driven by subtle drift in specificity of TFs, but primarily caused by cis-regulatory changes (Carroll, 2000; Levine and Tjian, 2003), with some contribution from relatively large shifts in binding specificities of specific TFs.

Both mechanisms result in diverged specificities for the novel binding domains and over time the specificity of the domains can drift extensively.

DOI: http://dx.doi.org/10.7554/eLife.04837.028 To detect more subtle drift in TF specificity, we analyzed conservation of dinucleotide preferences resulting from structure-based TF-DNA recognition (Rohs et al., 2010; Jolma et al., 2013).

To characterize the role of divergence and subtle drift in TF DNA binding specificity in animal diversity, we used HT-SELEX to determine TF binding specificities in Drosophila melanogaster.

In books like Austerlitz and The Emigrants, paragraphs begin with numbing specificity and then continue for pages, drifting in and out of various characters' points of view.