Sentence examples for specificity determination from inspiring English sources

The presented structure-based approach is generalizable to other protease enzymes with known or modeled structures, and complements existing experimental methods for specificity determination.

The FGF receptors and co-receptors for these three FGF molecules have been identified, and domains important for receptor interaction and specificity determination are beginning to be elucidated.

The multi-step mode of action of the Cry insecticidal proteins allows various factors to potentially affect specificity determination and here we define seven levels that could influence specificity.

Most single-residue clusters are directly involved in enzyme substrate interactions, whereas multi-residue clusters are vital for domain domain and regulator enzyme interactions, indicating their complementary role in specificity determination.

These positions are known as specificity determination positions.

We used an alternative approach based on the prediction of Specificity Determination Positions (SDPs).

NTMs were not mentioned in the majority of studies, and, when reported, were usually excluded from specificity determinations.

Data from 213 patients were retrospectively analyzed using standard statistical methods including sensitivity and specificity determinations, binomial scoring, and t-testing.

GROUPSIM [34] was used to predict specificity-determination positions using default parameters except for maximum group gap (set to 0,1).

PKCβII can directly bind to actin, which in turn modulates its substrate specificity via determination of substrate proximity [58], suggesting that the actin cytoskeleton controls the target substrate and, therefore, the regulated signaling pathways [57].

This study shows that the combination of a specific TFO and a reduced activity methyltransferase variant can be used to target DNA methylation to predetermined sites with high specificity, allowing determination of crucial CpGs for promoter activity.