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The ultimate diagnostic sensitivity and specificity depend on the choice of cutoff.
Thornton and collaborators have shown in detailed evolutionary, structural, and biochemical studies of the evolution of ligand specificity in glucocorticoid receptors that evolutionary transitions in ligand specificity depend on coincidental presence of certain amino acid residues, enabling the functionally adaptive amino acid substitutions.
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R. microplus normally parasitizes a single host and it is believed this host specificity depends on the specific detection of bovine phenolic compounds [ 32].
In the context of cancer screening, optimal specificity depends on how many negative (unnecessary) biopsies one is willing to accept in order to detect one case of cancer.
There are a variety of different CRLs, each associating with a specific cullin protein and possessing different specificity, depending on the adaptor and/or substrate-specifying subunit used (Petroski and Deshaies 2005).
Its specificity depends on the differential spatiotemporal expression of downstream components specific to various cell types and developmental stages.
Changing the threshold in model A, we can vary sensitivity and specificity depending on needs.
Better understanding of this specificity depends on modelling studies based on ample structural and biochemical information.
However, the overall change in specificity depended on the target compound.
CD8+ T cell specificity depends on the recognition of MHC class I epitope complexes at the cell surface.
We suggest that the specificity depends on the stabilization of an enol tautomer of the 8-oxo form of dGTP.
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