Sentence examples for specificity coupled from inspiring English sources

This absence of a simple relationship between sequence, structure and binding specificity, coupled to the low level of sequence conservation between KAP-βs, makes determining the evolutionary origins and history of KAP-βs challenging.

Ideally, the first assay should thus have a 100% sensitivity combined to a good specificity and the second test used to confirm the initial positive results should have a 100% specificity coupled to a good sensitivity.

These interactions are characterized by high specificity coupled with low affinity, ensuring their transient character, selectivity and reversibility.

These include the need for high levels of sensitivity as well as specificity, coupled with quantitative, multiplex capabilities and high sample throughput.

Because of high sensitivity and specificity coupled with the requirements for only a water bath and endpoint detection using a color-change reaction visible with the naked eye [ 32- 34], LAMP assay has been applied for the analysis of various infections from Mycobacterium tuberculosis, Norovirus, Human papillomavirus, Cytomegalovirus, and Human immunodeficiency virus [ 20, 35- 38].

That we can resolve the G protein binding specificities at the base of each of these clades, but not at deeper nodes, suggests an early diversification of G protein binding specificities, coupled with relative stasis of protein interactions once the major opsin clades were established.

We did this by using a set of individually low sensitivity/low specificity biomarkers coupled with clinical data to create high sensitivity/high specificity estimations that can inform surgeons when to close wounds to maximize the likelihood of healing and minimize the risk of dehiscence.

This redirects LRH-1 binding as predicted and showed that, in this case, evolutionary importance and binding specificity are coupled sufficiently strongly for the Evolutionary Trace to guide the computational design of DNA binding specificity.

This specificity allows coupling to a system bus comprised of an LC resonant loop.

These linkages are examined using three key concepts from theories of organization design: formalization, specificity, and coupling.

The specificity for coupling to the stimulatory guanine nucleotide regulatory protein lies within a region extending from the amino terminus of the fifth hydrophobic domain to the carboxyl terminus of the sixth.