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According to the following measures the clustering computed by LInCS lies between the two levels: it covers 880 proteins instead of only 609 in level 4 but it is already almost perfectly specific: for all clusters the minimal specificity concerning biological process categories is 0.99, for all molecular function categories it is 1.0 and for all cellular component categories it is 0.99.
The frequent replacement of wild-type amino acids by proline at major protease cleavage sites indicates that at least pepsin- and chymotrypsin-like enzymes may exhibit a (conformational) specificity concerning the P1 and P2 positions.
It will be interesting to investigate whether other putative synapto-nuclear messenger than CREB2 or Jacob exhibit similar specificity concerning activity-dependent nuclear import following induction of synaptic plasticity.
Fbs1 is known to bind mannose rich polysaccharides without any specificity concerning amino acid sequence.
To our knowledge, there is no study about the sensitivity and the specificity concerning similar algorithms in the literature.
For aftercare interventions the specificity concerning the mentioned determinants inherently supposes an alignment at the necessities of chronic back pain as medical indication.
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Importantly, these data sets allowed us to make use of existing background knowledge on the disease progress and specificities concerning individual disease stages.
Only British Plebejus argus showed a higher α value (126.6 [ 60]), but this is due to specificities concerning populations extremely isolated in habitat islands within the British landscapes [ 60].
However, our approach may not be directly transferable to other countries, due to local specificities concerning e.g. a high autonomy of individual faculties in the creation of their curricula.
The specificity concern is exacerbated by the fact that the cells that bind E641 I-Ab and OVA323-339:I-Ab do not undE641 I-AbandexpansiOVA323-339 I-AbzatiOVA323-339 I-Ab
For GPCRs, serious specificity concerns have been raised in a number of articles contesting the reliability of many GPCR antibodies for IHC (e.g., [224]).
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CEO of Professional Science Editing for Scientists @ prosciediting.com