We calculated the strand-specificity, coefficient of variation, duplication rate, gap rate, ribosomal RNA rate, exonic rate, insert size, and GC content of each aligned set of reads [Additional file 4].
In the first and second levels, i.e. nucleotide and binding site levels, sensitivity, specificity, performance coefficient and F-measure are computed based on the true positive (TP), false positive (FP) and false negative (FN) information gathered by comparing the predicted and actual binding sites.
The accuracy of the models was assessed using six measures: sensitivity (Sn), specificity (Sp), correlation coefficient (CC), simple matching coefficient (SMC), average conditional probability (ACP), and approximate correlation (AC).
The sensitivity, specificity and Kappa coefficients were calculated from the individual examiner's 'most hypomobile' finding compared to the CBV gold standard (Table 1).
Data on three pregnancy complications (placental abruption, PPROM, and fetal anomaly) and multiplicity were available in both DNPR and DMBR and there were no difference in sensitivity, specificity, and kappa coefficients.
Secondary objectives were concordance explored by Kappa coefficient, specificity, positive predictive value (PPV) and likelihood ratios.
The classification accuracy, sensitivity, specificity, Matthews correlation coefficient (MCC), and area under the curve (AUC) values for proposed method are 97.54%, 97.22%, 97.60%, 0.9193, and 0.9868, respectively.
The classification accuracy, sensitivity, specificity, Matthews correlation coefficient (MCC), and area under the curve (AUC) values for current method were 78.31%, 80.05%, 72.23%, 0.5836, and 0.8800, respectively.
Sensitivity, specificity, and kappa coefficient with 95% CIs were calculated for each group separately.
Based on these assumptions, the values for sensitivity, specificity and kappa coefficient would be 0.23, 0.99, and 0.31, respectively.
