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Training Test Accuracy 84 71 Precision 80 76 Sensitivity (class S) 85 70 Specificity (class NC) 87 67 F-measure 82 73.
Representatives of each specificity class have been studied at molecular and genetic levels.
Beside their altered substrate specificity, class II CDHs are not restricted to work under acidic pH conditions.
We then created 'consensus networks' that combine the local network neighborhood of all GTs, predicted to belong to the same specificity class and of which the local subnetworks are enriched in the same GO terms.
To gain insight in the mutual interactions between GTs and of these GTs with other proteins involved in the same process, we created 'consensus networks' that combine the local network neighbourhood of all GTs, predicted to belong to the same specificity class and of which the local subnetworks are enriched in the same GO terms.
The results associated with the classification model established by AFP are shown in Table 2. Table 2 Validation statistics derived from the best AFP model established on 42 non-sensitisers and 167 sensitisers using 7 DRAGON descriptors Training Test Accuracy 93 90 Precision 95 94 Sensitivity (class S) 96 100 Specificity (class NC) 79 75 F-measure 96 96.
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Recent large-scale analyses of mouse [6] and human [7] data sets showed that PDZ-ligand interactions are highly specific, with distinct specificity classes evident among the binding motifs [7].
Furthermore, for the subcategory "sexual Q < 0.1", we did not find a statistically significant enrichment in any of the phylogenetic specificity classes, although the Neurospora orphans and Pezizomycotina-specific genes together comprised the majority of the "sexual Q < 0.1" genes (51%).
16 distinct specificity classes were recently reported for the PDZ domain family [84].
TFs enabling specific responses (small regulon size) tend to establish relatively more FFLs with their regulated genes than those inducing less specific responses (large regulon size; the decay of FFLness with regulon size is generally observed, i.e., even when specificity classes are not explicitly considered, data not shown).
Like in OligoRAP (3) and IMAD (4) pipelines, probes are assigned to different Target Specificity Classes (Table 1), based on the amount and type of hits (5).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com