However, in conclusion we examined the performance characteristics of a novel ELISA to detect Ma2 autoantibodies in blood of SI-NET patients by measuring the sensitivity and specificity capacity in discriminating patients from healthy individuals.
In-depth analysis of specificity, capacity, affinity and avidity of all the peptide candidates is underway on matrix, sonicated samples and GAG-coated plates to select targeting leads for evaluation in preclinical studies.
Antigen-specific T-cells can be evaluated by their peptide target specificity, proliferative capacity, cytokine secretion, cytolytic activity, and membrane markers of activation.
To improve the binding specificity and capacity, PNGase F treatment is often required beforehand to remove N-linked GlcNAc-terminating sugars on proteins/peptides.
There were various mutations identified in the SULT enzyme family and they were reported to exhibit different catalytic specificity and capacity in each polymorph form [ 15].
This suggests that the open chromatin environment established by the UCOE simply allows a linked, nearby promoter to function with its normal specificity and capacity.
Their nonimmunogenic nature, small size, high specificity, and capacity for multiple transcript regulation are reasons to expect their presence in RNA viruses.
The specificity and capacity of these antisera were analysed by incubating the antisera with recombinant human IL-1α, IL-1β, TNF-α, and IL-6 in the presence of soluble IL-6 receptor and IL-17.
Mutations (e.g. deletions, fusions) that affect the integrity of transcription factors by altering their DNA-binding specificity and/or capacity to interact with cofactors can transform these proteins into potent oncogenes.
These differences could well alter the peptide-binding specificity and capacity of these class II allotypes and their interactions with T-cell receptors, in particular the glycine to valine difference at position 86, a residue that forms part of peptide binding pocket 1 and has been associated with disease susceptibility previously and peptide binding 16, 17.
Even though proximal tubular endocytosis is regarded as a low-specificity, high-capacity pathway, it can be blocked competitively by excesses of ligands [ 30, 31].
