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Hydrogen bonding provides the specificity behind the matching of complementary pairs of single-stranded (ss) DNA to hybridize into a double strand (ds) of helical DNA.
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The structure also reveals the molecular mechanism behind the specificity of FGF18 for FGFR c-isoforms and the reduced affinity for these compared to FGF8b.
This observation does not rule out the possibility that dynamics of the flap could be a factor behind linkage specificity.
The molecular mechanisms behind this strict host specificity are unclear, but several human-specific pathogen host interactions have been recently revealed using biochemical approaches.
The argument suggests that such risks are not nearly so pronounced in the biobanking context and therefore the justification behind the high specificity threshold is limited (section 13).
In contrast, the reason behind the NSCLC specificity of EML4 ALK is unclear.
An important component to doing so is elucidating the mechanism behind how KAT specificity is regulated.
The biological mechanism behind this subsite specificity is unknown, but differences in the embryonic tissues of the colon and rectum and in patterns of growth factors and receptors may be relevant (Chyou et al, 1996; Bonithon-Kopp and Benhamiche 1999; Wei et al, 2004).
This highlights the increasing specificity assumption as the key property behind the developmental hourglass effect.
The mechanism behind this strict host specificity is not yet known.
Interestingly, proteomic-transcriptomic combination panels have achieved good sensitivity, specificity and accuracy, but are lagging behind the transcriptomic panel in these performance measures [ 46].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com