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We used various statistical measures such as Accuracy, Sensitivity, Specificity, Balanced Classification Rate (BCR) and Receiver Operating Characteristic (ROC) to evaluate the models.
The cut-off points were calculated by the MedCalc software as the points with the best sensitivity-specificity balance.
The best sensitivity-specificity balance for PSD of FDT was 37.3%–93.3%, respectively (cut-off point > 3.99).
The best sensitivity-specificity balance was observed for vertical C/D ratio in both devices: 94%-93% for Cirrus OCT and 90% 94% for HRT3.
Divalent cations affect integrins affinity and specificity; a balance between calcium, zinc, magnesium, and manganese may modulate integrin binding to its substrate [ 14– 17].
BACC ((Sensitivity + Specificity)/2), balanced prediction accuracy.
Legend: BACC (Sensitivity + Specificity)/2, balanced prediction accuracy.
Specifically, to balance sensitivity and specificity, we fix each compartment threshold such that the model renders the correct number of positives on the annotated set.
Table 1 shows the best single term for high-sensitivity, high-specificity, and best balance of sensitivity and specificity.
Table 4 shows the 3 top-performing search strategies for best sensitivity, best specificity, and best balance between sensitivity and specificity.
We therefore consider these two generic cut-offs to well balance specificity and generalizability and thus to be most appropriate to describe frequent attendance in German primary care.
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