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Separation of this region was specifically chosen to maximize specificity at the expense of sensitivity.
Taken as a whole, this work illustrates two specific mechanisms of DNA-protein specificity at the Parvovirus origin of replication.
This research serves as the foundation for the future design of mosquito-specific expression cassettes with predicted stage- and tissue specificity at the desired levels of transgene expression.
Deborah Polaski sang the stepmother, and, though she supplied her usual glowering intensity, she competed unsuccessfully with my vivid memories of Anja Silja, who sang this role with ferocious psychological specificity at the Deutsche Oper, in Berlin, last year.
However, these approaches improve CRISPR specificity at the cost of reduced efficiency.
Sensitivity and specificity at the level of 0.0038 ng/mL were 81.3% and 81.2%, respectively.
Decision rules with a higher specificity at the cost of missing fractures were considered unsuitable.
The IRS had 0.84 sensitivity and 0.55 specificity at the cut-off point of 6.5.
High specificity at the nucleotide level, however, is per se insufficient for region specificity.
We thus accepted a rule that maximised sensitivity and specificity at the expense of not achieving 100% sensitivity.
However, interferon-γ assays that use RD1 antigens in isolation may maximise specificity at the cost of sensitivity.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com