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Specificity arising from the 5-quinoline moiety was associated with a distinct pattern of water-mediated hydrogen bonds involving Lys235 and Glu248 in the inactive conformation favoured by ALK2.
A possible worlds approach based on Kripke structures is developed, and it is shown that this approach resolves various problems that arise in a first-order setting, including specificity arising from nested quantifiers in a formula and an analogue of the lottery paradox that arises in reasoning about default properties.
However, the relative joint specificity arising from immunity toward an antigen whose expression is not joint restricted is puzzling.
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Such DNA-binding specificity arises from protein-specific residues that interact with flanking regions of the canonical "CACGTG" motif.
At the cellular level, does specificity arise by signaling to only specific parts of the neuron, such as regions of axon competent for synapse formation (as suggested by the specific localization of UNC-40/DCC in the PHB axon [ 1]), and does the developmental state of the receiving neuron matter?
Although the AGs are limited to specific participants, it is unknown at what stage specificity arises, and seed fate pathways in AG epiphytes are undocumented.
Specificity arose because the organization of Cre-binding repeats of the preferred substrate matched the programmed arrangement of the subunits in the heterotetrameric synapse.
Our results demonstrate that TCR specificity arises from the distributed action of numerous sites throughout the interface, with significant implications for engineering therapeutic TCRs with novel and functional recognition properties.
How this specificity arises is an important question for the future.
Taken together, TGF-β signaling specificity arises from spatiotemporal dynamics of Smad phosphoisoforms.
Low specificity arose from the frequent occurrence of enlarged, hyperplastic nodes, particularly in patients with postobstructive pneumonitis[ 16 ] (Fig. 9).
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