Further study on its target specificity and selectivity is required to the design of selective analogues.
Substitutions that deleteriously affect the affinity, specificity and selectivity of a beneficial motif will generally be under negative selection and will fail to spread through the population.
Ideally, a radiotracer should possess high specificity and selectivity for the target of interest in order to obtain specific and highly quantifiable imaging data.
Addition of a specific HNF4α antibody shifted the bands, therefore providing clear evidence for the specificity and selectivity of the assay.
The dilutions and concentrations of antibodies were selected based on previously studies in rodent brain documenting their specificity and selectivity [28].
Moreover, it was demonstrated the ability of the device of realizing specific, combined time and space resolved analysis of the sample, with elevated specificity and selectivity.
This high specificity and selectivity of action is also accompanied by development of tumor antigen-specific memory T cells, which can prevent cancer recurrence.
In order to enhance vascularization, immobilization of integrin-specific RGD peptidomimetics within constructs is a recommended approach, due to their high specificity and selectivity towards certain desired integrins.
New drug characterization assays are central in providing evidence to the specificity and selectivity of drugs.
The pharmacological specificity and selectivity of [18F]CFT for monoamine transporters ex vivo are reported.
The probe has shown considerable photostability, cell permeability, organelle specificity and selectivity for ATP.
