Sentence examples for specificity and selective from inspiring English sources

The Wnt-Frizzled specificity and selective Frizzled expression dictate the stereotyped, topographic positioning of synapses between these two neurons.

Soler, D. et al. The binding specificity and selective antagonism of vedolizumab, an anti-alpha4beta7 integrin therapeutic antibody in development for inflammatory bowel diseases.

Cardiac troponins are tests with high sensitivity and specificity and selective biomarkers for diagnosis of acute myocardial infarct.

In detail, we found a low nanomolar affinity (K d = 1.8 nM), high binding specificity and selective fluorescence accumulation in CCK2R-expressing tumours in mice.

Whether the specificity and selective pressures in the C. femoratus-P.

Furthermore, CD4+CD28null T cells isolated from the synovial fluid were investigated with regard to antigen specificity and selective recruitment to the joint.

Further study on its target specificity and selectivity is required to the design of selective analogues.

However, one of the limitations to the use of liarozole is its lack of specificity, and more selective inhibitors of RA metabolism are needed (reviewed in Njar, 2002).

How TORC1 signaling could control Rsp5-dependent cargo specificity and the selective ubiquitinylation of many different cargoes at the same time is currently not clear.

The inclusion of healthy controls is likely to lead to over estimations of specificity and the selective inclusion of cases with more advanced disease is likely to lead to over estimations of sensitivity [ 58].

Thus, combination therapy or the use of the second generation of mTOR inhibitors, which include mTOR and PI3K dual-specificity inhibitors and selective mTORC1/2 inhibitors, may overcome some of the limitations of rapalogs and exhibit improved antitumor activity.