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In the latter case, specificity and functionality of the brain tissue limit the options available to surgical and chemotherapeutic treatments.
The design of vaccines that induce robust and long-lasting protective CD8 T-cell responses however imposes new challenges, as many factors such as kinetics and efficiency of antigen-processing and presentation by antigen presenting cells, T-cell repertoire and cytokine environment during T cell priming contribute to the specificity and functionality of CD8 T-cell responses.
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In this study, we applied the in vitro MMR assay to analyse the substrate specificities and functionality of MutS α and MutS β using substrates, GT, IDL1 and IDL2 in three different cell lines.
To assess the substrate specificities and functionality of MutS α and MutS β we performed an in vitro MMR assay using three substrate constructs, GT mismatch, 1 and 2 nucleotide insertion/deletion loops (IDLs) in three different cell lines.
The analysis confirmed the absence of MSH2, MSH6 and MSH3 in both LoVo and GP5d NEs, thus making them suitable for substrate specificity and functionality studies of MutS α and MutS β.
In many cases, a specific structure is crucial for biological specificity and functionality.
These engineered cells retained antiviral specificity and functionality, and contained a subset with regulatory phenotype and function.
What of the implementation and functionality of the technology?
We also examine the utility and functionality of the pieces.
Envision and design the look and functionality of your website.
This suggests that post-translational modification (PTM) in response to drug may be involved in substrate specificity or functionality of BCRP [104].
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