Sentence examples for specificity and alternative from inspiring English sources

This discrepancy between mammalian and yeast protein evolution was explained by the specialization of more than 150 cell types in mammals (Vogel and Chothia 2006) that requires additional layers of gene regulation (e.g., tissue specificity and alternative splicing) associated with multicellularity and organismal complexity (Schad et al. 2011) to influence protein evolution (Gu and Su 2007).

The current study tested the specificity of and alternative explanations for this trajectory.

Spotted 70-mer oligonucleotide arrays offer potentially greater specificity and an alternative to expensive cDNA library maintenance and amplification.

Assuming null sensitivity and specificity equal to 0.85 and alternative sensitivity and specificity equal to 0.95, as well as α = 0.05, β = 0.2, and a case to control ratio equal to 1 : 2, a sample size including 75 cases and 152 controls was needed to test the sensitivities.

This is likely due to cells adjusting their substrate specificities and activating alternative lipid biosynthesis feedback loops over the 3 day duration of the RNAi experiment.

However, Wagner et al (2013) showed that FPKM data still exhibit experiment specificity and proposed an alternative corrected measurement, TPM, to account for these differences.

Therefore, processing single sample datasets from one sequencing platform with multiple variant-calling pipelines should not be the long-term solution for generating variant calls with high sensitivity and specificity, and we discuss alternative approaches below.

However, as many other biomolecules likewise absorb UV light, the specificity is generally low, and alternative detection techniques are usually preferred also to achieve better sensitivity.

The results confirm our previous findings of up-regulation in antimicrobial peptide expression and provide a comprehensive overview of changes in and the specificity of gene expression and alternative splicing after exposure to 2 strains of C. bombi.

A secondary aim of the study is to examine the summary estimates of sensitivity and specificity of alternative cut-off scores to optimally discriminate between fallers and non-fallers.

We sought to determine the sensitivity and specificity of alternative monitoring regimens in predicting the need for a second methotrexate (MTX) dose in women undergoing medical therapy for ectopic pregnancy.