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The concept of knowledge specificity addresses this issue of decoding endogenous reciprocity in the triple helix.
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With further experimental characterization and validation, it opens a possible channel for the development of novel treatments with high target specificity, addressing both host toxicity and resistance concerns.
We evaluated the sensitivity and specificity, addressing different database search scenarios at different levels of difficulty.
These revisions simplify the Criteria, preserve their diagnostic sensitivity and specificity, address their applicability across populations, and may allow earlier diagnosis and more uniform and widespread use.
Distinguishing exposures of limited duration or periods of specific relevance (e.g., in utero) from chronic exposures may lend useful specificity for addressing some research questions.
Solubility and structural specificity were addressed with simple physical approximations of aggregation and conformational equilibria.
The issues of potential zinc toxicity and of zinquin specificity were addressed by the inclusion of the irrelevant metal ion, Ni2+, which failed to influence zinquin fluorescence (Figure 3B).
It is essential that, in particular the point about outcome-relevant specificity, is addressed appropriately.
A1R and P2Y1R antibody specificity was addressed further by Western blot analysis, using rat whole brain and hippocampus membrane fractions (Fig. 2D and E).
The present work combines endpoints with the aim of improving phase II trial sensitivity and specificity while addressing the need for intuitive measures.
Both morpholinos were tested for their specificity by addressing the same knockdown analysis, and after determining they had the same effects, they were used interchangeably for further experimentation with similar outcomes in repeats of the same experiment.
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