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But I do think that she's right to call attention to the historical specificities on which the genre (if, indeed, it's a genre) thrived.
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Residue 102 mutations frequently result in different levels of substrate specificity, depending on which protein they are made in.
Feruloyl esterases can be classified into four types based on sequence homology and substrate specificity depending on which synthetic methyl esters of various hydroxycinnamic acids they are able to cleave and on whether they are able to release diferulic acid [ 15].
Immunohistochemical evaluations based on antibodies the specificity of which is not well defined may therefore lead to mis-interpretation of the likelihood that a tissue will respond to oestrogens via full-length ERβ.
Now, to the specificity of which, we'll find out — you'll find out with time.
Previously, Gibbs and co-workers observed in studies using a series of modified isoprenoid diphosphates that peptide substrate specificity varied depending on which particular isoprenoid was used.
In addition, Figure 1a also displays the varying sensitivity and specificity percentages depending on which PSSCAN score is used as the cut-point.
Multiple Pto-like proteins are encoded in the tomato genome, and it has been shown that Prf recognition specificity is altered depending on which homologue it interacts with [ 39, 40].
Taken together, these results demonstrate that KINspect successfully identified a set of residues on which the specificity of the entire domain is encoded.
The sensitivity and specificity of these criteria were tested on a set of 250 pre-miRNAs from 24 different organisms (Additional File 2) and a set of 30770 randomly selected sequences from T. brucei genome (random sequences matching the selected criteria were considered false positives, based on which the specificity was estimated).
A recognised limitation in this and other studies is the choice of gold standard investigation on which sensitivity and specificity values are based.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com