Despite the previously reported genetic compartmentalization and gp120-specific bias of colostrum HIV Env-specific B cells, the colostrum Env-specific mAbs described here demonstrated a broad range of gp120 epitope specificities and functions, including inhibition of epithelial cell binding and dendritic cell-mediated virus transfer, neutralization, and antibody-dependent cellular cytotoxicity.
These tissue-specifically expressed genes represent the most important set of genes that determine the specificities and functions of the five sampled tissues.
Despite great strides in the understanding of the specificities and functions of human antibodies produced in response to flavivirus infections, much remains to be discovered about how they act together to protect against infection or occasionally worsen disease11.
There are many enzymes hydrolyzing nucleic acids with different specificities and functions, many with vital internal metabolic roles.
To characterize cellular immune responses during recovery, we analyzed the appearance, specificity and function of MeV-specific T cells for 6 months after respiratory infection of rhesus macaques with wild type MeV.
Long, E. O. et al. Killer cell inhibitory receptors: diversity, specificity, and function.
Tomassian, T. et al. Caveolin-1 orchestrates TCR synaptic polarity, signal specificity, and function in CD8 T cells.
Monoclonal antibodies to ligand-occupied conformers of integrin alpha IIb beta 3 (glycoprotein IIb-IIIa) alter receptor affinity, specificity, and function.
In vivo, chaperones also associate with a large and diverse set of cofactors (cochaperones) that regulate their specificity and function.
We derived an optimal criterion for the specificity and function for flexible biomolecular binding where the binding and conformational folding are coupled.
