Rodda, S. J. & McMahon, A. P. Distinct roles for Hedgehog and canonical Wnt signaling in specification, differentiation and maintenance of osteoblast progenitors.
These techniques, together with gene expression profiling, are useful for analyzing epigenomic regulation of cell specification, differentiation, and function during zebrafish development in both normal and disease models.
CSL (CBF-1/RBP-jκ, Su(H), Lag-1) drives canonical Notch-mediated gene transcription during cell lineage specification, differentiation, and proliferation in the hematopoietic system, the intestine, the pancreas, and the skin.
The developing compound eye of Drosophila has long been a model of choice for addressing this question by dissecting the cellular, genetic and molecular pathways that govern cell specification, differentiation, and multicellular patterning during organogenesis.
Phenotypic analysis demonstrates that the identified PAL-1 target genes affect specification, differentiation and morphogenesis of C-lineage cells.
During heart developmental processes, cell fate determination, specification, differentiation and migration are all involved.
The specification, differentiation, and migration of PGCs are governed by a tightly controlled series of gene expression events [6].
The foundations of the primitive heart form between gastrulation and early organogenesis, as critical specification, differentiation, and morphogenic events occur.
Notch signals normally participate in a variety of cellular processes, including cell fate specification, differentiation, proliferation, apoptosis, migration, and angiogenesis [1].
Numerous cell type-restricted basic helix-loop-helix (bHLH) transcription factors have been identified and shown to control cell fate specification, differentiation and morphogenesis during development [9], [10], [11].
