This approach is based on dynamic regression models, combined with a genetic algorithm for the semi-automatic selection of the best model over a large model space, covering different specifications of the correlation structure within clusters and different specifications of the systematic components of the model.
Such a set of solutions was created by the specification of a systematic grid of goal programming weights, enabling the decision maker to choose the solution that achieves the desired trade-off level.
It involves, on the one hand, the specification of facts through systematic observation, measurements and experiment, and on the other hand, the clarification of ideas through the exposition of the definitions and axioms that are tacitly implied in those ideas.
By looking at only Cochrane systematic reviews, we suspect that our study underestimates bias due to changes in outcome specification during the systematic process.
The meaning facets provide a conceptual framework for a systematic specification of the meaning of a bio-model and consequently are the basis for rigorous semantics of the bio-model.
However, for a systematic formal specification of the meaning of bio-models it is very useful to distinguish between the intrinsic and the extrinsic interpretation.
Specification of the research questions: this is considered to be the most important part of the systematic review, as these questions will guide all the following steps, as the search for primary studies, extraction and analysis of information.
The h3′UTRome v1 library is a modular resource that can be utilized for high-throughput screens to identify regulatory interactions between trans-acting factors and 3′UTRs, Importantly, the library can be customized based on the specifications of the researcher, allowing the systematic study of human 3′UTR biology.
Specification of the dissemination mechanisms and formulation of the report: dissemination of the results attained by the systematic review.
Specification of indicators and systematic data collection will be needed to provide confirmation of their being achieved.
