Additional file 1: Table S3 shows that, for all specifications of interest, the probit model provides similar results to those coming from the linearized regression models.
In the third column, with the most flexible non-parametric specification, the coefficients of interest on the year × market structure interactions are negative in 2006, 2007 and 2008.
The independent a priori specification of regions of interest was based on previous studies of Tower of London and Spatial Rotations Tasks (Williams-Gray et al., 2007 b ; Hampshire et al., 2012).
This review adhered to international recommendations and guidelines in order to reduce bias in publication selection, including pre-specification of inclusion/exclusion criteria and pre-specification of indirect comparisons of interest.
Multivariate risk models require careful attention to accurate measurements, a priori selection of the primary outcomes and risk factors of interest, specification of data collection including any missing values, and assessment of collinearity and any confounding or effect modification.
This paper introduces the PSM (Phenomenon of interest, Specification and operationalization, Mechanism) approach to embed mechanisms describing particular dynamics of interest within the broader picture of an overall transition.
Following specification of all variables of interest as well as their interrelationships, the validity of an ecological model (or of any of its components) is often tested by analysis of variance (ANOVA -based procedures, either through experimentation, 'screening' of predictors, or simulation.
Nonetheless, given that all the models could be considered 'valid' it reasonable to argue that the choice of superior model should rather be based on which model is fit for purpose what specification of demand is of interest.
Alone, a regional analysis in order to quantify the 2D tissue distribution requires manual manipulation time, depending on the number and anatomical specification of the regions of interest.
Previous analyses have relied on manual cell region of interest specification or averaging across multiple slices to provide substantial insights (Yamaguchi et al., 2003; Evans et al., 2011; Enoki et al., 2012; Maywood et al., 2013).
