Assuming a fit cell population can withstand accrued damage and the compounding of irreversible molecular changes longer than aged cells, specification by means of differential expression analysis of those aberrations that take place before a cell slithers into the final state of senescence was expected to yield meaningful insights.
The scope of our research questions includes theory-based analyses of the mechanisms involved in the expected behaviour change (i.e., mediators) as well as à priori specification of subgroups for differential analyses (moderators).
The continuous state change can be specified by a combination of indirect specification via ordinary differential equations, or direct specification via assignment of variables to values that depend on time, or indirect specification by demanding that behaviour obeys a time dependent predicate.
The specification of such a small differential (6.75percentt vs 9.99percentt) adds fuel to a fire of discontent.
Differential specification of micromere lineages along the dorsoventral axis is correlated with early divergence of cell division rate and geometry [12].
Additionally, not enough is known about the differential specification of PV- and SST-positive subgroups within the Nkx2.1-expressing lineage of interneuronal progenitors.
Previous studies indicated that the brn3-hb9- phox2-based differential specification of the somatic and visceral neurons is conserved outside vertebrates, at least to some degree.
Unequal Numb distribution during mitosis determines Notch (N) activities, which direct differential specification of the sister cells in various neuronal lineages (e.g. Spana and Doe, 1996; Tio et al., 2011).
In our material, En2 signal is first restricted (up to E16.5), in a gradient decreasing caudalwards, to the ventricular zone of Is-r1r, but is lost by E18.5, suggesting a transient role in the differential specification of the local serotonergic derivatives (isDR, r1DR, CLi and MnR).
We expect that our reclassification of raphe nuclei may be useful for causal analysis of their differential molecular specification, as well as for studies of differential connectivity and function.
Some type of differential interaction between specific Nrx and NL isoforms may drive the functional specification of each synaptic connection [4], [10] [12], although the precise mechanism underlying such a process remains unknown.
