Sentence examples for specification mutants from inspiring English sources
(3) Neuron specification mutants.
Neuron specification mutants can be helpful in identifying candidate cells for functions such as chemosensation.
We used three types of mutants: (1) cilium structure mutants which have defects in the sensory endings of ciliated sensory neurons, (2) sensory transduction mutants which lack components necessary for signal transduction, and (3) neuron specification mutants which lack transcription factors that are necessary for the correct development and function of specific neurons.
In contrast, conditional inactivation of Mib1 in various tissues revealed the representative Notch phenotypes: defects of arterial specification as deltalike4 mutants, abnormal cerebellum and skin development as jagged1 conditional mutants, and syndactylism as jagged2 mutants.
The first service is represented by the predicate impactIsSpecifiedBy (inverse for specifiesImpact) and, for a given mutation impact, retrieves a mutation specification containing protein and mutant information, which in part answers the service request.
tll is expressed in procephalic neuroblasts and required for their specification as tll mutants lack the anterior brain [ 62]. dpn encodes a pan-neural gene shown to be expressed in all neuronal lineages during embryogenesis as well as in neuroblasts of the larval CNS and in precursors of sensory neurons in imaginal discs.
To evaluate the impact of experimental conditions that delayed endoderm specification in Dido3 mutant EB, we screened EB for markers representative of undifferentiated ES cells and of all three germ layers.
sev is only required for R7 specification and consequently sev mutants do not contain R7 cells [22].
Given that S is the specification of P, a mutant is said to be fault-revealing when it leads to the creation of a test case that shows that P t)≠S t), t∈T) ([42] p. 536).
Importantly, these Dlx1/ 2 double mutants exhibit incorrect specification of the LGE/CGE, with inappropriate expression of ventral cortex markers [ 110, 111].
They pointed out that Nkx2.5 null mutants cause over-specification of cardiac progenitors and that the area of over-specification of cardiac progenitors appears to be a broad expression of early cardiac markers in the cardiac crescents.
