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The Wnt signalling pathway comprises a family of secreted glycoproteins with functions relating to cell specification, formation of the body plan, cell growth, differentiation and apoptosis.
Interestingly, the approximately 25-day gap between epidermal specification (formation of the first two layers of cells) and stratification (formation of all other epidermal layers) does not occur in mammals.
Wnt proteins are a family of secreted cysteine-rich glycoproteins with functions relating to cell specification, formation of the body plan, cell growth, proliferation, differentiation and apoptosis [ 3- 5].
Using rat as a model, the authors showed that the translation of DPYSL2B mRNA is localized in the axon and is regulated by mTOR through the action of its effector, 70-kDa ribosomal S6 protein kinase (p70S6K), leading to the specification, formation, and maintenance of the axon.
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SGG/GSK-3 are a master switch in the Wnt/Wingless Wg) pathways and are involved in fundamental developmental processes in animals such as cell fate specification, pattern formation and body axis formation [ 2, 6, 7].
Neuronal polarization, involving the initiation of immature neurites, the specification and formation of axon and dendrites, and the formation of synaptic contacts, is essential for signal transmission in the central nervous system (CNS) (Arimura and Kaibuchi, 2007; Dotti et al., 1988).
In Drosophila, the proper specification and formation of PGCs require both centrosomes and germ plasm, which contains the germline determinants.
Jonathan Slack's Essential Developmental Biology (Slack 2006, 2013) is organized around four main types of processes, also described as clustered groups of problems, which occur during embryonic development: regional specification (pattern formation), cell differentiation, morphogenesis, and growth.
This review summarizes the current knowledge about WNT/FZD selectivity and functional selectivity, the role of co-receptors for signal specification, the formation of receptor complexes as well as the kinetics and mechanisms of signal initiation with focus on WNT/β-catenin signaling.
Understanding the evolution of germ layers will be assisted by the analysis of the evolution and expression of genes conserved in bilaterian mesoderm specification and formation, along with further analysis of developmental processes in these taxa.
The action of TBX20, a member of the TBX1 subfamily of T-box proteins, is necessary in early stages of heart development, by coordinating cardiomyocyte proliferation and regional specification and formation of cardiac chambers and valves [ 12].
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