Sentence examples for specification commitment from inspiring English sources

It has been reported to regulate macrophage differentiation [30], has a critical role in the development of myeloid cells [31] and is likely involved in B-cell lineage specification, commitment and differentiation [32].

Moreover, IRF8 is a critical transcriptional regulator of B cell lineage specification, commitment, and differentiation in mice [ 65].

This lack of a specific early germ cell reporter might explain why the characterization of human PGC specification and commitment in vitro has not been investigated until now.

Since these properties are formal, they can easily be incorporated in a software tool to (semi- automate the desemi- automateficathen of commitment protocols.

The in vitro differentiation of embryonic stem cells (ESCs) represents an accessible system for analyzing parameters influencing the early stages of lineage specification and commitment.

We noted a convergence of findings, leading to a set of transcription factors which are involved in the early T-lymphocyte specification and commitment as well as in oligodendrocyte dedifferentiation and development.

These transcription factors are involved in early T-lymphocyte specification and commitment as well as in oligodendrocyte dedifferentiation and development, both pathways that have significant biological plausibility in MS causation.

To further elucidate this possibility we investigated under these culture conditions the expression of some of the relevant growth factor receptors known to be required for signal transduction pathways relevant in specification and commitment to PNS neuronal differentiation [21].

Critical factors for early B cell specification and commitment are E2A, early B cell factor 1 (EBF1) and Pax5 and other factors play important roles at later stages (reviewed in [1] [4]).

These two tissues lie in direct contact during this time, and a large body of evidence indicates that signals from the neuroectoderm of the ventral diencephalon (hypothalamus) are required for the induction, specification and commitment of Rathke's pouch and pituitary cell lineages [for review see 19].

ES cells that lack Nanog may comprise a spectrum of phases between lineage specification and commitment.