The biological concepts captured in the domain model are translated into a software specification, and the architecture and organization of the simulation software are designed.
We demonstrate efficient hepatocyte specification, cell organization, and significant improvements in cell function and phenotype.
We show that the interphase centrosome does not define spindle orientation in female GSCs and that DSas-4 mutant GSCs [7], lacking centrioles and centrosomes, invariably divide asymmetrically to produce cystoblasts that proceed normally through oogenesis remarkably, oocyte specification, microtubule organization, and mRNA localization are all unperturbed.
QC is that part of cGRPP concerned with sampling, specification and testing, and with organization, documentation and release procedures, which ensure that the required and relevant tests are actually carried out and starting and packaging materials and finished products are only released if their quality complies with the requirements.
Wnt signaling was blocked at various time points by heat-shock treatments and we observed perturbations to precursor cells specification, organization and patterning in all three tissue layers of the swimbladder.
We used multiple markers of NCCs and their derivatives to assess when these phenotypes arise, and found Int6 did not appear to be required for the specification or organization of premigratory and migrating cartilage precursors (Figure S2).
NudE is a component of the dynein motor complex (Shu et al. 2004; McKenney et al. 2010) that is implicated in several transport processes linked to oocyte specification: fusome organization, centrosome migration, and RNA transport into the pro-oocyte (Theurkauf et al. 1993; Bolivar et al. 2001; Navarro et al. 2004).
Subsequent conditional blocking of Wnt signaling at various developmental stages showed that the precursor cells specification, organization, and patterning in were all perturbed in the three tissue layers.
Resources and organization.
