Sentence examples for specification and maturation from inspiring English sources

Various studies have begun to characterize the specific roles played by REST and CoREST complexes during NSC-mediated neuronal lineage specification and maturation.

During germ-cell specification and maturation, epigenetic reprogramming occurs and the DNA methylation landscape is profoundly remodelled.

The specification and maturation of hemocytes are determined during development by the expression of markers particular to each cell lineage.

We also identified mediators of TGF-β signaling, including BMP-related pathways, such as Dcp1a and Smad2, both of which are involved in neural patterning, specification and maturation.

Exclusive REST target genes and exclusive CoREST target genes were selectively enriched for distinct pathways highlighting potential differences in the roles played by REST and CoREST in regulating developmental processes important for glial lineage specification and maturation.

Although REST and CoREST are believed to orchestrate neurogenesis by regulating the expression of neuronal differentiation genes, our ChIP-chip studies suggest that these factors are also important for modulating NSC-mediated glial lineage specification and maturation.

Many members of the HSC lineage do not possess the HSC potential and cannot function as stem cells; they have to undergo specification, selection and maturation to become fully operative dHSCs.

Additional concerns relate to the limited control over cardiomyogenic specification and cardiomyocyte maturation in vitro as well as the risk of teratocarcinoma formation and immune rejection of stem cell implants in vivo.

For example, REST and CoREST targeted genes are involved in key developmental pathways that mediate AS specification, including Notch, JAK-STAT, BMP, FGF, and EGF signaling, and OL specification and progressive maturation, such as PDGF, SHH, MAPK, and FGF signaling (Table S1) [76].

In various combinations and permutations, REST and CoREST also target genes encoding factors with key roles in OL specification and progressive maturation, including basic helix loop helix (bHLH) (e.g., Mash1/Ascl1, NeuroD4/Math3, and Id4), high-mobility group (HMG) (e.g., Sox2, Sox8, and Sox11), and POU domain (e.g., Pou3f2) transcription factors (Table S4).

In particular, our model suggests that there must be at least two separate signaling events controlling luminal cell differentiation: specification as a BLP (which may or may not be concurrent with secretory/ciliated specification), and, separately, maturation of that cell into a differentiated luminal cell.