It does this through identification of problems, specification of intervention, and the comparison and evaluation of outcomes of treatments.
Publication of the preliminary phases can provide theoretical and feasibility detail and specification of intervention components which can begin to address concerns [ 13, 14].
The following key steps are required: The first step for contextualizing WHO-CHOICE cost-effectiveness figures involves the specification and definition of interventions to be included in the analysis, including a clear description of the target population, population-level coverage and, where applicable, the treatment regimen.
Early publication of this complex intervention development and evaluation data will enable clinicians and future systematic reviewers to determine the specification and evidence base for intervention components.
Some commentators identify problems with the quality of evidence, in terms of research design, study size, research setting, intervention specification and outcome measurement, all of which are frequently limited [ 101, 102].
Improved specification of intervention components and hypothesised causal pathways linking components to outcomes would lead to improved evaluations (Acevedo-Garcia, et al., 2004, Thomson et al., 2009).
The differences in the setup and specification of the intervention of the relevant trials make such an approach prone to additional bias and therefore difficult to assess the benefits and harms of the intervention.
6 The selection and specification of interventions, in cases where a WHO-CHOICE regional analysis was available, corresponded closely to the interventions defined in the prior analysis.
The specification of the intervention strategies and their relationships to intervention targets (step 3) will improve clarity of current intervention techniques and their proposed pathways of change.
Less controversially, there is consistent evidence that effectiveness of an intervention is dependent on attention to the importance of audience characteristics [ 22], the need to tailor interventions to individuals [ 38], and the necessity of clear specification of intervention [ 39].
