Sentence examples for specification and commitment from inspiring English sources

This lack of a specific early germ cell reporter might explain why the characterization of human PGC specification and commitment in vitro has not been investigated until now.

The in vitro differentiation of embryonic stem cells (ESCs) represents an accessible system for analyzing parameters influencing the early stages of lineage specification and commitment.

These transcription factors are involved in early T-lymphocyte specification and commitment as well as in oligodendrocyte dedifferentiation and development, both pathways that have significant biological plausibility in MS causation.

To further elucidate this possibility we investigated under these culture conditions the expression of some of the relevant growth factor receptors known to be required for signal transduction pathways relevant in specification and commitment to PNS neuronal differentiation [21].

Critical factors for early B cell specification and commitment are E2A, early B cell factor 1 (EBF1) and Pax5 and other factors play important roles at later stages (reviewed in [1] [4]).

We noted a convergence of findings, leading to a set of transcription factors which are involved in the early T-lymphocyte specification and commitment as well as in oligodendrocyte dedifferentiation and development.

Vice versa, the metabolic status of the cell affects its specification and lineage commitment and thus greatly influences the representation of functional effector cells in the host's immune system.

These observations suggest that lin-12 activity contributes to robustness of β−cell specification and fate commitment at elevated temperature, even though lin-12 activity is not absolutely required for a β cell to adopt the VU fate.

Thus, hyaluronan receptor Lyve-1 [ 6], the prospero-related homeobox gene transcription factor Prox1 [ 7], the membrane glycoprotein podoplanin (Pdn)/D2-40 [ 8], vascular endothelial growth factor receptor- (VEGFR-) 3 tyrosine kinase [ 9], and its ligands VEGF-C and VEGF-D [ 10] have been documented in the specification and lineage commitment of the lymphatic system.

During mammalian development, cardiac specification and ultimately lineage commitment to a specific cardiac cell type is accomplished by the action of specific transcription factors (TFs) and their meticulous control on an epigenetic level.

Again, terms associated with cell differentiation, such as cell fate specification and cell fate commitment, were observed.