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p21-activated kinase (PAK) binds specifically to active Cdc42 and Rac (Chuang et al, 1997).
This promoter contains 7 tandem repeats of an auxin-responsive TGTCT element, which has been shown to respond rapidly and specifically to active auxins, as many early auxin response genes do, by binding auxin response factors (ARFs) [ 46- 48].
A time-dependent Caspase 3 activation was demonstrated in oxaliplatin-treated cells by immunostaining with a fluorescently labelled antibody that binds specifically to active Caspase 3, and quantified using flow cytometry.
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To examine whether CatD was more active in L803-mts treated cells, cells were stained with pepstatin A BODIPY, which binds specifically to the active form of CatD.
In case of KLK1 an engineered antibody bound specifically to the active site of the tryptic protease, resulting in inhibition of the peptidase activity with an inhibition constant around 130 pM, paving the way for a novel cure of asthma [294].
Our aim was to find new inhibitors that bind specifically to the active site.
To verify the hypothesis that the organic solvents bind specifically to the active site and especially to the S-pocket of the ThDP-dependent enzyme ApPDCE469G, molecular modelling studies are currently being conducted.
Cue-triggered increases in efforts to obtain sucrose were directed specifically to the active lever that had previously earned sucrose reward during training, and not to the other lever (Two-way ANOVA (drug × lever), F3,79 = 3.25; p < 0.05, significant interaction; Figure 4).
Thus, methyl viologen reduction could be specifically attributed to active [FeFe] hydrogenase in the cell lysates and not the maturases or native E. coli [NiFe] hydrogenases.
However, recent evidence indicates that PIKE-A, one of the three isoforms of AGAP2, specifically binds to active AKT [37], and that PIKE-A is a proto-oncogene capable of promoting cell proliferation and invasion [38].
Importantly, Rab26 is excluded from active zones immunostained for the Bruchpilot (Brp), a scaffold protein specifically localized to active zones (Wagh et al., 2006).
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CEO of Professional Science Editing for Scientists @ prosciediting.com