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Our results show that senescence-secreted factors specifically sensitize pretransformed cells to TRAIL-induced apoptosis and that sensitization is mediated through a biphasic Myc-dominated gene programming.
At least as attractive, and not mutually exclusive is the hypothesis that arterial injury, like in early atherosclerosis, will up-regulate endothelial expression of proteinase-activated-receptor 2 [53], which will be activated proteolytically within the atherosclerotic lesion and via systemic proteases to specifically sensitize endothelial TRPV4 channels to respond to mechanical stress [34].
Two compounds were found to specifically sensitize MRP1-expressing cells without inducing cellular GSH depletion.
* Sets of targets whose inhibition might specifically sensitize tumor cells with the indicated mutation, but allow normal cells to survive by entering cell cycle arrest.
The potential of 2-DG to provide an adjuvant metabolic stress to specifically sensitize cancer cells to Dasatinib was next tested in vivo.
For certain sets, inhibitions of the target proteins might specifically sensitize tumour cells with the indicated mutation, but allow normal cells to survive by entering cell cycle arrest (asterisks in Table 3).
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This information, conveyed to the local lymph glands via the lymphatic vessels, leads to the formation of specifically sensitized lymphocytes.
Controlled human exposure studies have produced conflicting results regarding the effect of ozone on the early bronchoconstrictor response to inhaled allergen in specifically sensitized asthmatic subjects.
These data suggest that H2O2 mediated oxidative stress specifically sensitized T98G cells to heat, and stress kinases may be only marginally involved in the enhancing effect.
In children not specifically sensitized the evidence is more sparse, although more positive than negative.
There was documented association, biologic plausibility, and apparent causality in specifically sensitized individuals.
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CEO of Professional Science Editing for Scientists @ prosciediting.com