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Oncolytic viruses are known to stimulate the antitumor immune response by specifically replicating in tumor cells.
NVM's disruptive angle is in the area of contact centers, specifically replicating — for a fraction of the price — the offerings based on costly customer premises equipment that helps customer service teams route calls, offer automated responses and integrate live responses with customer record access.
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Douglas E. Winter has opined that Tenebrae's Louma crane sequence was stylistically influential and was specifically "replicated in Brian De Palma's The Untouchables (1987)." In Raising Cain, De Palma's "surprise reveal" of John Lithgow standing behind a victim is often discussed as being an unacknowledged "steal" from Tenebrae.
Other oncolytic viruses including reovirus, measles virus, VSV and NDV, seem to have an inherent capability to specifically replicate only in tumor cells, leaving normal cells largely unaffected.
Conversely, Rep5 specifically replicated an ITR comprised of ITR2 hairpins and hairpin spacer and the ITR5 spacer and nicking stem (ITR2+5SNS, Fig. 1B).
(1, 2) This idea was exemplified by an adenoviral vector that specifically replicates in p53-deficient cells, a genetic feature often associated with cancer cells.
Among mammalian reoviruses, reovirus type 3 Dearing (T3D) specifically replicates in cancer cells, resulting in efficient tumor cell lysis but not in normal tissues.
Oncolytic herpes simplex virus (HSV) vectors that specifically replicate in and kill tumor cells sparing normal cells are a promising cancer therapy.
Reoviruses are naturally occurring viruses that are non-pathogenic and have been reported to specifically replicate in cancer cells with an activated Ras pathway but not in normal tissue.
The mitochondrial transcription and replication imaging protocol (mTRIP) is a modified fluorescence in situ hybridization approach that specifically targets replicating mtDNA nucleoids and can simultaneously be used to exhibit transcription activity by targeting mtRNA.
Oncolytic herpes simplex virus-1 (HSV-1) is designed to specifically infect, replicate in, and lyse cancer cells.
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