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Targeted pre-trans-splicing RNA molecules efficiently and specifically repaired mutated lacZ transcripts and restored enzymatic activity in human cells.
Collecting system defects were specifically repaired and the integrity assessed with retrograde instillation of methylene blue.
UV damage is specifically repaired by nucleotide excision repair (NER), and common genetic variants in NER may increase risk for non-melanoma skin cancer (NMSC).
These guanine O-6 lesions are specifically repaired by MGMT, and a 22-fold greater clonogenic LC90 value was observed in L1210 cell lines expressing MGMT.
Processing mutants of CFTR's sister protein, the P-glycoprotein (P-gp) drug pump, can be specifically repaired by a drug rescue approach.
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Several studies have shown that these photolyase enzymes can efficiently and specifically repair DNA lesions within one hour when provided with photo-reactivation light [ 10, 14, 19].
NER-deficient XPA cells were stably transfected with CPD-photolyase or 6-4PP photolyaspecificallyically repair only CPD or only 6-4PP.
Because CFTR and P-gp are predicted to be structurally similar, it may be possible to specifically repair CFTR processing mutants by a direct drug rescue approach using small molecules.
We attribute this result to the narrow substrate specificity of hOGG1 which specifically repairs 8-oxoG opposite cytosine [ 18, 19, 56, 57] and has little or no affinity for other lesions.
The Msr family consists of a single enzyme, called MsrA, which specifically repairs the S-form of PMSO and three separate enzymes, called MsrB1, MsrB2 and MsrB3, which collectively recognize the R-form of PMSO.
The former involves the BRCA/FA pathway and specifically repairs "fatal DNA double strand breaks".
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CEO of Professional Science Editing for Scientists @ prosciediting.com