Finally, the same data set also showed that alternative A-rich noncanonical poly(A) sites are more likely to be tissue specifically regulated compared with A(A/U UAAA alternative poly(A) sites (Supplementary Figure 3B).
In addition, the expression of genes implicated in signalling processes, cell adhesion and structure, protein modification, transport and metabolic processes is specifically regulated by treatment with EGF or shows a pronounced alteration in comparison with that in oestrogen-treated cultures (Fig. 1).
We aim to identify differentially regulated genes during early infection, to make inferences about pea immune-related pathways that are commonly or specifically regulated during interaction with these two oomycetes pathogens.
Interestingly, a number of major pro-apoptotic regulators including Bax and Bak were also specifically regulated upon STS treatment with almost identical expression profiles.
When a 2.5 fold expression cutoff was applied on the Mc52 sample, 1,918 of the regulated genes (32.1%) were specifically regulated at the merozoite stage, with 1,249 being upregulated and 669 genes downregulated at this stage.
However, without a suitable methodology to specify the significance of these events, we may confuse alternative with specifically regulated polyadenylation.
There are 162 genes specifically regulated under chimeric development, with continuous small differences between chimera vs. clone over development.
There are 3,645 genes identified by either main effect or interaction effect, and 162 genes are specifically regulated under chimeric development, with a characteristic expression pattern that features continuous small differences between chimera vs. clone over development (Additional file 1: Figure S3).
We identified 1024 genes (955 genes were specifically expressed in ovules tissues when compared to others tissues) that were specifically regulated during these developmental stages, along with many highly stage-specific genes.
Some reports have shown that the deprivation of glucose is able to attenuate neurosphere formation efficiency but no neuronal maturation by human periodontal ligament-derived MSCs [ 46] and that glucose deprivation-induced necrosis, a distinct hallmark of the metabolic stress present in solid tumors in combination with hypoxia, is specifically regulated by Egr-1 [ 47].
