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With this, much of this review focuses on describing the biological barriers to nanomedicine delivery, and how polymer nanomaterials can be designed to specifically overcome this large hurdle in nanomedicine.
PLG-binding/activation through the proteins/receptors on the surface of Leptospira could help the bacteria to specifically overcome tissue barriers, facilitating its spread throughout the host.
PLG-binding/activation through the proteins/receptors on the surface of Leptospira could help the bacteria to specifically overcome tissue barriers, facilitate invasion and colonize mammalian tissues.
Further understanding of the mechanisms underlying glycolysis induced facilitated DNA repair and radio-resistance may help in unraveling critical molecular targets responsible for resistance and facilitate the design and/or identification of molecules/agents that specifically overcome resistance linked to enhanced glycolysis, thereby enhancing the efficacy of radio- and chemotherapies.
To ensure that p16INK4a-mediated cell cycle arrest was specifically overcome by expression of its CDK4 and CDK6 binding partners, we also transiently introduced CDK2, a kinase that accelerates and augments CDK4/6-initiated Rb hyperphosphorylation (reviewed in Johnson & Walker, 1999; Sherr, 1993).
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5. Provide suggestions for future research specifically overcoming the limitations of the current study.
In this regard, we are unsure as to why AmphoB specifically overcomes IFITM2 and IFITM3 while leaving IFITM1's actions predominantly extant.
In this paper we describe the emergence of a P. viticola isolate (isolate SL) that specifically overcomes Rpv3, the major resistance gene carried by Bianca at chromosome 18.
In this paper we describe the characterisation of a P. viticola isolate that specifically overcomes the resistance from the grapevine cultivar Bianca.
Our approach specifically overcomes the limitation of the conventional homology-based approach by taking into account two important factors: (i) differences between eukaryotic and prokaryotic proteins, and (ii) differences between intra-species and inter-species PPI interfaces.
These results show that SL is not an especially aggressive isolate of P. viticola, but rather that it specifically overcomes the resistance carried by Bianca at the Rpv3 locus and can thus be considered an Rpv3 resistance-breaking isolate.
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Justyna Jupowicz-Kozak
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