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Specifically, neutralizing IL-10 signaling expedited time-to-death for eight P. chabaudi genotypes, and death curtailed transmission potential (Long et al. 2008a).
In a model of rheumatoid arthritis, an antibody specifically neutralizing only the SLAYGLR domain of mouse OPN (homologous to the SVVYGLR of human OPN) greatly abrogated monocyte migration towards the thrombin-cleaved form of OPN and inhibited the proliferation of synovial cells, bone erosion, and inflammatory cell infiltration in arthritic joints [ 21].
In principle, the same reasoning applies to the treatment of DCM with cyclic peptides specifically neutralizing β1-adrenoceptor autoantibodies (proposed by Jahns et al., 2006a; 2010), while it should not play a role in therapy regimen employing extracorporeal elimination of all IgG.
Here we present new evidence supporting our hypothesis that, by specifically neutralizing IFN-α, these autoantibodies decrease expression of ISGs in APECED peripheral blood cells.
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To address this question we used a neutralizing, antibody (huRANKL MAb), which specifically neutralizes the biological activities of human RANKL and thereby the contribution of C4-2 deRANKL RANKL in this tibial injection model of experimental bone metastases.
To show the specificity of the reactions, we preincubated cells with antibodies previously shown to specifically neutralize either human VEGFR2; IMC-1121b (Zhu et al, 2003) or human VEGFR3; hF4-3C5 (Persaud et al, 2004), by binding to the ligand-binding part of the extracellular domains.
These colony-stimulating factor-induced effects were specifically neutralized by the corresponding antibodies.
Antibodies to aa496 515 were isolated by affinity binding and elution from the serum of a vaccinated chimpanzee and found to specifically neutralize chimeric 1a/2a, 1b/2a and 2a HCVcc.
They specifically neutralize free radicals that have the potential of doing some real damage in your body.
Importantly, this group subsequently reported that antiserum raised against this synthetic peptide could specifically neutralize HIV in vitro [13].
Since bee defensin-1 is the only cationic bactericidal compound present in RS honey [14], addition of SPS to this honey specifically neutralizes bee defensin-1.
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