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It is still possible that this cleavage is occurring due to another protease, but given that it can be inhibited by pepstatin A, this would specifically necessitate an aspartyl protease capable of cleaving at or very close to the endoproteolytic site of γ-secretase, which would seem to be an unlikely combination.
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Failure was defined as the failure to resolve loculated effusion or a complication necessitating intervention (specifically bleeding that necessitates fluid resuscitation and/or further intervention).
Highly polyploid species are particularly challenging for assembly and may necessitate specifically tailored assembly pipelines (Schatz et al. 2012).
Rapid diagnostic tools, specifically for malaria programs necessitates to be adapted to local environments and utilized by local workers as control strategies campaigns during severe epidemiological and entomological manifestations [ 48].
The preparation of host complexes which will specifically bind a given guest necessitates structural analysis of the potential complexes formed, as well as an assessment of the strength of the binding interaction.
The new UV light polymerization technique proved to be highly suitable to obtain ultrathin sections being cut parallel to the surface of the embedded material, an advantageous feature for applications which necessitate the examination of specifically oriented or laminated structures.
This necessitates use of age-specific body weights and intake and specifically refutes the claim that an adult body weight and dose can represent risk across a lifespan.
The advent of biosimilars 92 has also necessitated the development of new guidelines specifically for such products and will be another area requiring careful regulation and monitoring.
Human blood develops from self-renewing hematopoietic stem cells to terminal lineages and necessitates regulator and effector gene expression changes; each cell type specifically expresses a subset of genes to carry out a specific function.
Specifically, both Mike Hussey and Nathan Hauritz suffered significant injuries both of which necessitated surgery.
This, however, necessitates the availability of architecturally clean and specifically deuterium labelled model polymers due to the sensitivity of the scattering method.
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