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This methodology leverages a promiscuous galactosyltransferase, an azide-modified substrate, and strain-promoted click chemistry to specifically modify the heavy chain glycans, the conserved, N-linked bianntennary oligosaccharide chains positioned on the CH2 domain of the Fc region, far from the antigen binding regions.
Much of the advancement in mouse models for cancer during the past 2 decades can be attributed to our increasing capacity to specifically modify the mouse germ line.
The ability to rapidly and specifically modify the genome of mammalian cells has been a long-term goal of biomedical researchers.
We have shown that this drug is able to specifically modify migraineur's abnormal behaviour in sensorial processing, confirming previous results obtained using CNV, an event-related cortical evoked potential.
We developed a novel yeast-based screening procedure designed to detect compounds that specifically modify multidrug resistance due to an interference with the expression of drug efflux transporter genes.
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T cells specifically modified to express the GD2-specific chimeric receptor 14. G2a-28 ζ efficiently interacted with Ewing sarcoma cells, resulting in antigen-specific secretion of cytokines.
Although the structure of the muscular, skeletal, and other anatomical systems are specifically modified for each group, amphibians are often set apart from other groups of animals by their characteristic skin, or integument, and evolutionary advances in vision and hearing.
All of the numerical investigations were carried out by specifically modifying the control stope.
It is in fact a nanofiber whose surface chemistry can be site- specifically modified [1].
The properties of optical minigastrin probes can be specifically modified by the introduction of spacer sequences.
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