Allele-specific gene silencing by RNA interference (RNAi) is therapeutically useful for specifically inhibiting the expression of disease-associated alleles without suppressing the expression of corresponding wild-type alleles.
Necrostatins, a series of small-molecule inhibitors, suppress necroptosis by specifically inhibiting RIP1 kinase activity.
Specifically inhibiting Akt activity may be a valid approach to treat cancer and increase the efficacy of chemotherapy.
In this study, we present a new strategy to target TGF-β TGF-βling casignaling specascadesy inhibyting the exprespecifically-β type inhibiting theBR1 (ALK5).
It was found to act by specifically inhibiting the activity of the kinesin Eg5, and has opened up a whole new aspect to cell cycle research and enabled completely new modes of inhibiting cell growth.
It exerts its action by specifically inhibiting the HMG-CoA reductase, the enzyme that catalyzes the conversion of HMG-CoA to mevolanate, which is the early rate-limiting step in the biosynthesis of cholesterol in the body.
However, the fact that HDACs 1, 2, and 3 are recruited to several large multi-subunit complexes, each with particular biological functions, raises the possibility of specifically inhibiting individual complexes.
Fungicides are used to control fungal disease by specifically inhibiting or killing the fungus causing the disease.
It is the first member of a new class of agents that act by specifically inhibiting a certain enzyme that is characteristic of a particular cancer cell, rather than non-specifically inhibiting and killing all rapidly dividing cells.
We suggest that LEKTI-2 contributes to the regulation of the desquamation process in human skin by specifically inhibiting KLK5.
Prior to addition of toxins, cells were preincubated for 45 min at 37°C in medium lacking FCS and with substances specifically inhibiting endocytic pathways.
