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In order to specifically inhibit SIK1 activity, we used a gene-specific RNAi-based approach.
Certain derivatives have been found to specifically inhibit FcyB-mediated [3H]-adenine uptake.
We have applied engineered transcriptional repressors to specifically inhibit disease gene-activated pathways in oncogenesis.
We show that block decoys are exonuclease-resistant and specifically inhibit expression from target binding sites.
Compounds 7a specifically inhibit EGFR and erbB2 receptor at 0.081 and 0.098 μM concentration.
siRNA was shown to specifically inhibit mutant KRT9 mRNA and protein expression (p < 0.01, with 95% confidence limits).
The function of expressed olfactory receptors was further validated using MDL12330A, which can specifically inhibit the activity of adenylyl cyclase.
To define which trafficking pathway a SNARE of interest is involved in, one needs to specifically inhibit its function.
Several novel biologic agents have been designed to specifically inhibit different aspects of tumor growth and progression.
In both cellular systems, siRNAs could specifically inhibit MDR1 expression up to 91% at the mRNA and protein levels.
Current information indicates that some small molecules, known to specifically inhibit PPs, might be developed as nematocides.
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