Together, the data indicate that the hippocampus is specifically engaged in regulation of responses to psychogenic stressors, in keeping with its role in cognitive processing and emotion.
We have proposed that SLC25A1 is one of only a handful of gene targets identified thus far, associated with mutp53 GOF activity and specifically involved in regulation of cellular metabolism.
The sak1 mutant is specifically impaired in regulation of a notable subset of these genes, that is, those that are most strongly induced in the wild type (Table 5), suggesting that these genes play a key role in the acclimation response to O2.
In an effort to address this question we studied the role of a tissue specific transcription factor, Foxi1, in regulation of both specifically e.g. B1 and a4 as well as ubiquitously expressed subunits e.g. A1 and E2.
A very natural place to study gene regulation is in the metabolism of the cell, and then specifically in the regulation of genes that code for enzymes and transporter proteins.
Refined molecular technologies and the creation of genetically engineered mice have allowed to specifically target individual genes involved in regulation of corticotropin releasing factor (CRF) system elements (e.g. CRF and CRF-related peptides, their receptors, binding protein).
More recently, acetylation of histone H3 at lysine 27 (H3K27ac) was described to specifically mark active enhancers engaged in regulation of RNA polymerase activity through chromatin looping [ 7, 8].
These observations suggest two possible roles for H3K36me3 in pre-mRNA splicing, and specifically in the regulation of pre-RNA splicing.
Furthermore, there has been no genomic profiling specifically investigating the involvement of RpoS in regulation of virulence genes in enteropathogenic E. coli and other related pathogens.
Loss of centromeric cohesion in pans1 during meiosis II could be due to defects in regulation of cohesion specifically during meiosis II, or alternatively could also be connected to defects in centromere organization during meiosis I.
