Sentence examples for specifically impairing from inspiring English sources

The present study demonstrates for the first time a specific role for CaM in nuclear import of HMG-box family nuclear factors, as well as the central importance thereof for SRY's role in sex determination, in that CaM-NLS mutations specifically impairing CaM binding/SRY nuclear import result in sex reversal.

The most informative mutations in this respect are the M64T/R76P CaM-NLS and R133W β-NLS (see [ 10]) mutations, none of which markedly affects DNA binding and bending, all only specifically impairing the nuclear import pathways mediated by the NLS in which they are mutated.

Together, these data suggest that partial loss of LIN-12/Notch signaling activity spares vulval morphogenesis but specifically impairs vm2 specification and muscle arm development, and that muscle arm development might require a higher level of LIN-12/Notch signaling activity compared with earlier developmental events (see 'Discussion').

USP52 knockdown specifically impaired the hypoxia response, as it caused no such impairment to the NF-κB (nuclear factor κB) response after TNFα (tumour necrosis factor α) stimulation of the HeLa C57A cell line [ 20] (Supplementary Figure S1B).

MiR199b-5p exprespecificallyimpairsimpairs the cancer-stem-cell (CD133+) population, which results in vivo in impairment of MB tumor development in the cerebellum xenograft mouse model, thus providing proof of concept.

When processes of place-value integration are specifically impaired in neglect patients, especially with regard to the tens digits, a specific modulation of the compatibility effect by neglect may be expected.

crl1 is specifically impaired in crown root initiation, while crl2 is impaired in the initiation and subsequent elongation of crown roots.

First, blocking the outputs of α/β core neurons during consolidation stage but not retrieval stage specifically impairs 24-h aversive LTM (Huang et al., 2012).

We determined the structure of the co-assembled lattice by electron cryo-microscopy and designed mutations that specifically impair the lattice formation in vitro.

With this novel Cath E activation approach, it is possible to detect pancreatic cancer cells accurately and specifically impair their viability, while sparing normal cells.

Disrupting the rostral lateral frontal region specifically impaired behavioral performance of the most complex task-switching condition, in comparison to the caudal target region and the control region.