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Claims of functionality of alternative transcripts should depend on observation of phenotypes specifically dependent on the integrity of the proposed coding region of the alternative isoforms.
Although these genome-wide profiles indicate that nucleosome occupancy is generally affected by Chd1, they do not reveal which subsets of genes are specifically dependent on Chd1 function, and what the molecular basis of this dependency might be.
The main task is the design of selective compounds, which bind targets more specifically, dependent on the desired mode of action of the particular drug.
Today, as I walked through the morning mist, I began thinking that music is a universal language -- specifically dependent on prevailing technology and social organization but in no way bound by them (it was a philosophical kind of morning -- freezing temperatures for four straight months tends to do that to a person).
These results demonstrate that the attenuated virulence phenotype of KKF332 is specifically dependent upon loss of FopC.
This bos1 activation was specifically dependent on the production and secretion of the PelB and/or PelC pectate lyases.
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The airway was visualized, and the bronchoscope was advanced down the right mainstem bronchus first, until reaching point 6. 0.75 mL/kg of 1% Tween was instilled at this point in order to specifically target dependent lung regions.
6, 7 However, there is no such information available specifically for dependent type 2 diabetic patients.
Furthermore, while 23% of PDGF targets are specifically PI3K dependent, only 5% of FGF targets are repressed by PI3K alone.
Specifically, the dependent variables, either PCS or MCS, were regressed for sex, age, ethnicity, education, household income, employment, and number of chronic diseases.
Specifically, the dependent variables included for MANOVA were neurocognitive (RPM, JLOT, and TOL) and social-cognitive (FP subscores and IRI) measures.
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