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At the cellular level the AuNPs-PEI-FA specifically delivered siRNA into LNCaP cells, a prostate cancer cell line overexpressing prostate specific membrane antigen (PSMA, exhibits a hydrolase enzymic activity with a folate substrate).
Nothing says "well-rounded character" like a performance specifically delivered to remind us that with their "ways", little tramps like Penny always end up getting what they deserve.
This demonstrates that EGF-HPPS specifically delivered its cargo (DiR-BOA) to target cells via EGFR-mediated endocytosis.
Fluorescence intensity was significantly stronger at tumor mass of MDA-MB231 cells than solid mass of NIH3T3 cells, indicating that HAssLG nanoparticles were specifically delivered to tumor cells.
This property potentially makes them highly selective for killing targeted single cancer cells, provided that they can be specifically delivered to tumor cells, internalized, and transported to the cell nucleus [3].
Our immunohistochemical results showed that a large number of CD44 receptors were expressed on the 4T1 cell membrane, while few were observed in the cytoplasm, indicating that CD44-PEG-GNCs can be specifically delivered to 4T1 cells.
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We studied the use of oligobranched peptides containing the sequence of the human regulatory peptide neurotensin (NT4) as specific tumor targeting agents that can selectively and specifically deliver effector units for cell imaging or killing to tumor cells [ 6, 8].
We found that by linking NKG2D to IL2, we were able to specifically deliver IL-2 to the tumor location, enhancing antigen-specific T-cell immune response and controlling tumor growth [ 15].
It has been reported that rHDL could specifically deliver its encapsulated payload into the cytoplasm via the non-endocytic pathway [16].
Nanoparticles can potentiate radiotherapy by specifically delivering radionuclides or radiosensitizers into tumors, therefore enhancing the efficacy while alleviating the toxicity of radiotherapy.
Properly designed nanocolloids are capable to cross the blood brain barrier and specifically deliver the drug in the brain tumor tissue.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com